Nucleic Acid Integrated Technologies for Electrochemical Point-of-Care Diagnostics: A Comprehensive Review


SÜRÜCÜ Ö. , Ozturk E., KURALAY F.

ELECTROANALYSIS, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Review
  • Publication Date: 2021
  • Doi Number: 10.1002/elan.202100309
  • Title of Journal : ELECTROANALYSIS
  • Keywords: Point-of-care testing, healthcare, nucleic acids, electrochemistry, CIRCULATING TUMOR DNA, ON-A-CHIP, GLUCOSE BIOSENSORS, SENSING PLATFORM, OXIDATIVE STRESS, PAPER, SENSOR, LABEL, IMMUNOASSAY, PERFORMANCE

Abstract

The need for routine and immediate healthcare monitoring has inspired "near-patient testing" or in other words "point-of-care testing (POCT)". Therefore, POCT can be defined as laboratory tests that are performed at the patient's bedside or in the immediate vicinity of the incident. Among many POCTs, nucleic acid-based testing has attracted enormous attention for the diagnosis of important genetic, inherited and infectious diseases such as cancer and coronavirus. In this review, we outline the integration of nucleic acids into the remarkable electrochemical point-of-care diagnostics including microfluidic, paper and smartphone-based approaches, CRISPR/Cas and liquid biopsy related systems and DNA damage monitoring.