Cellular Protein Homeostasis in Health and Disease

Protein homeostasis, or proteostasis, is maintained by the concerted efforts from various cellular processes that control the synthesis, folding, posttranslational modification, assembly/disassembly, localization, and degradation of proteins in the cell. 

Proteostasis-TR Research Group mainly focuses on unwanted protein degradation and its implications in health and diseases.  The Group aims to translate its basic science discoveries to finding of novel proteostasis-related drug targets and innovative new drugs against cancer, neurodegenerative diseases, metabolic diseases, ageing and age-related diseases.  


Recent Publications