Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells


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Alaca N., ÖZBEYLİ D., USLU S., Sahin H. H. , YIGITTURK G., KURTEL H., ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.28, ss.476-484, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28 Konu: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/tjg.2017.16742
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Sayfa Sayıları: ss.476-484

Özet

Background/Aims: Cholestasis, which results in hepatic cell death, fibrosis, cirrhosis, and eventually liver failure, is associated with oxidative stress. The aim of this study was to evaluate the effects of milk thistle (MT, Silybum marianum) and ursodeoxycholic acid (UDCA) or their combination on the activation of hepatic stem cells and on the severity of cholestasis liver injury in rats.