Investigation of maternal melatonin effect on the hippocampal formation of newborn rat model of intrauterine cortical dysplasia


BAKA M. , UYANIKGİL Y. , Ateş U., KÜLTÜRSAY N.

CHILDS NERVOUS SYSTEM, cilt.26, ss.1575-1581, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26 Konu: 11
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00381-010-1147-5
  • Dergi Adı: CHILDS NERVOUS SYSTEM
  • Sayfa Sayıları: ss.1575-1581

Özet

Objectives Cortical dysplasia is a cortical malformation resulting from any developmental defects during different periods of development. This study aims to investigate the hippocampal histopathological alterations in the neonates with cortical dysplasia due to the prenatal exposure to carmustine (1,3-bis (2-chloroethyl)-1-nitrosoure; BCNU) and the possible effects of prophylaxis with melatonin, a neuroprotective agent.