Investigation of maternal melatonin effect on the hippocampal formation of newborn rat model of intrauterine cortical dysplasia


BAKA M. , UYANIKGİL Y. , Ateş U., KÜLTÜRSAY N.

CHILDS NERVOUS SYSTEM, vol.26, no.11, pp.1575-1581, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 11
  • Publication Date: 2010
  • Doi Number: 10.1007/s00381-010-1147-5
  • Title of Journal : CHILDS NERVOUS SYSTEM
  • Page Numbers: pp.1575-1581

Abstract

Objectives Cortical dysplasia is a cortical malformation resulting from any developmental defects during different periods of development. This study aims to investigate the hippocampal histopathological alterations in the neonates with cortical dysplasia due to the prenatal exposure to carmustine (1,3-bis (2-chloroethyl)-1-nitrosoure; BCNU) and the possible effects of prophylaxis with melatonin, a neuroprotective agent.