Targeted tumor radiotherapy


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Unak P.

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, vol.45, pp.97-110, 2002 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45
  • Publication Date: 2002
  • Doi Number: 10.1590/s1516-89132002000500014
  • Title of Journal : BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
  • Page Numbers: pp.97-110
  • Keywords: Targeted Tumor Radiotherapy, radionuclide cancer therapy, high LET radiation, Auger electron radiotherapy, 7-ALPHA-SUBSTITUTED ESTRADIOL COMPLEXES, POTENTIAL ANTICANCER DRUG, COMBINED CHEMO-THERAPY, BETA-D-GLUCURONIDE, IN-VIVO EVALUATION, BREAST-CANCER, COLORECTAL-CANCER, LIVER METASTASES, CELL-DEATH, DNA-DAMAGE

Abstract

Targeted tumor radiotherapy is selectively delivery of curative doses of radiation to malignant sites. The aim of the targeted tumor radiotherapy is to use the radionuclides which have high LET particle emissions conjugated to appropriate carrier molecules. The radionuclides are selectively collected by tumor cells, depositing lethal doses to tumor cells while no admission occur to normal cells.