Lack of association between catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a Turkish population


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Bulut H., Pehlivan M., Alper S., Tomatir A. G. , Onay H. , Yuksel S. E. , et al.

GENETICS AND MOLECULAR RESEARCH, cilt.10, ss.4126-4132, 2011 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 10 Konu: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.4238/2011.october.31.12
  • Dergi Adı: GENETICS AND MOLECULAR RESEARCH
  • Sayfa Sayısı: ss.4126-4132

Özet

Accumulation of hydrogen peroxide (H2O2) and low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo patients. We investigated a possible association between the CAT exon 9 (Asp-389) gene and vitiligo susceptibility in the Turkish population. Thirty-four patients with vitiligo and 49 gender, age and ethnic matched controls were enrolled in the study. Genotyping was done by PCR-RFLP. The CAT exon 9 (Asp-389) genotype and allele frequencies of vitiligo patients did not differ significantly from those of healthy controls. We found no association between CAT (Asp-389) gene polymorphism and vitiligo susceptibility in Turkish vitiligo patients.