This paper investigates the role of state played in the regional innovation systems through state universities and legal and institutional set-up within Turkey. Initially, the paper will discuss the lack of regional perspective in policy-making that, until very recently, was predominant in Turkey. Secondly, the paper examines two salient laws that have ramifications for regional economics. The key elements in regional innovation systems can be split apart into two sections. On one side there are technology development regions/centres, and university-industry joint research centres. On the other side, taking into account the public research undertaken, there are the state universities, and the role that they play in the earlier mentioned centres/regions. The econometric analysis asserts that each of these elements has a positive and statistically significant effect on the patenting performance of regions.