beta(1) and beta(2)-adrenergic receptor polymorphisms and idiopathic ventricular arrhythmias

Ulucan, Cem; Cetintas, VİLDAN; Tetik, ASLI; Eroglu, Zuhal; Kayikcioglu, LATİFE; CAN, LEVENT; PAYZIN, SERDAR; Aydin, Mehmet; HASDEMİR, CAN

doi:10.1111/j.1540-8167.2008.01202.x

beta(1) and beta(2)-adrenergic receptor polymorphisms and idiopathic ventricular arrhythmias

Ulucan C., Cetintas V. , Tetik A. , Eroglu Z., Kayikcioglu M. , CAN L. H. , ...More

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, vol.19, no.10, pp.1053-1058, 2008 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 19 Issue: 10
Publication Date: 2008
Doi Number: 10.1111/j.1540-8167.2008.01202.x
Title of Journal : JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Page Numbers: pp.1053-1058
Keywords: ventricular tachycardia, genetics, tachycardia, arrhythmias, beta adrenergic receptors, OUTFLOW TRACT TACHYCARDIA, BETA(1)-ADRENERGIC RECEPTOR, DIAGNOSIS, ADRENOCEPTORS, MANAGEMENT, MECHANISM, MUTATION, DOMAIN, RISK, GENE

Abstract

Genetics and Idiopathic Ventricular Arrhythmias. Introduction: Idiopathic ventricular arrhythmias commonly refer to ventricular tachycardia (VT) and/or frequent/monomorphic premature ventricular contractions (PVC) in patients with structurally normal heart. Activation of sympathetic tone has been shown to play an important role in the provocation and maintenance of these arrhythmias. We investigated whether common single nucleotide polymorphisms in the beta(1) and beta(2)-adrenergic receptors are associated with idiopathic ventricular arrhythmias.