Bioevaluation of Tc-99m(CO)(3)-Guanine in vitro and in vivo


İÇHEDEF Ç. , TEKSÖZ S. , ÜNAK P. , SENOCAK K., MEDİNE E. İ. , Ertay T., et al.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.292, ss.739-743, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 292 Konu: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10967-011-1493-0
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.739-743

Özet

The aim of this study is to examine biological behaviour of radiolabeled guanine with [Tc(CO)(3)](+) core in vitro and in vivo. In vitro biological behavior of Tc-99m(CO)(3)-Gua was evaluated on Lung (A-549), Breast (MCF-7), Colonic (Caco) carcinoma cell lines and normal human bronchial epithelial (NHBE). Tc-99m(CO)(3)-Gua compound showed high uptake on A-549 cell line when compared to NHBE cell line. Biodistribution characteristics of Tc-99m(CO)(3)-Gua was evaluated using New Zeland Rabbits. Scintigraphic results showed that a high level of radioactivity was observed in the lungs and liver shortly after administration of the Tc-99m(CO)(3)-Gua and excretion takes place via both renal and hepatobiliary route. It was concluded that Tc-99m(CO)(3)-Gua could be used as a nucleotide radiopharmaceutical for imaging purposes.