It is predicted that yield characteristics will be affected in the negative direction as a result of future global warming. Genotyping gene regions affecting the yield characteristics of animals today and thereby contributing to minimizing this situation in which producers can be affected in the negative direction. The aim of this study is to determine genotype and allele distribution of PRL, GH and PROP1 genes of the indigenous goat breeds in Turkey. Unrelated 50 Anatolian Black, 50 Kilis and 50 Angora goat breeds are used as the sample of the study. The genotype and allele frequencies of PRL and PROPI were detected by using polymerase chain reaction-restriction fragment length polymorphism method. The GH polymorphism was determined by direct sequencing. C allele frequency of PROP1 and A allele frequency of the PRL was found to be high in Anatolian Black, Kilis and Angora goat breeds. Only BB genotype was observed in 5' promoter region GH gene. As a result, it can be suggested that these three genes need further investigation on more goat breeds and larger numbers of individuals and also further investigations should be carried out in order to understand the relations between gene and efficiency traits. Based on these, future studies on Anatolian breeds can lead to more definitive results.