Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)(2)(NH3)(2)] and cis-[Pt(tsac)(2)(NH3)(2)]

Al-Jibori, Subhi; Al-Jibori, Ghassan; Al-Hayaly, Lamaan; WAGNER, Christoph; SCHMİDT, Harry; TİMUR, SUNA; Barlas, F.; Subasi, Elif; Ghosh, Shishir; Hogarth, Graeme

doi:10.1016/j.jinorgbio.2014.07.017

Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)(2)(NH3)(2)] and cis-[Pt(tsac)(2)(NH3)(2)]

Al-Jibori S. A. , Al-Jibori G. H. , Al-Hayaly L. J. , WAGNER C., SCHMİDT H., TİMUR S. , ...More

JOURNAL OF INORGANIC BIOCHEMISTRY, vol.141, pp.55-57, 2014 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 141
Publication Date: 2014
Doi Number: 10.1016/j.jinorgbio.2014.07.017
Title of Journal : JOURNAL OF INORGANIC BIOCHEMISTRY
Page Numbers: pp.55-57
Keywords: Cisplatin, Ammine, Saccharinate, Thiosaccharinate, X-ray structure, Anti-cancer, PLATINUM(II) COMPLEXES, CRYSTAL-STRUCTURES, MOLECULAR-STRUCTURE, METAL-COMPLEXES, CROSS-LINKING, CISPLATIN, DNA, PALLADIUM(II), CIS, CIS-DIAMMINEDICHLOROPLATINUM(II)

Abstract

The new platinum(II) complexes cis-[Pt(sac)(2)(NH3)(2)] (sac = saccharinate) and cis-[Pt(tsac)(2)(NH3)(2)] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)(2)(NH3)(2)]center dot H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. (C) 2014 Elsevier Inc. All rights reserved.