Hyaluronic acid-modified [F-19]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs


Yasakci V., Tekin V., Guldu O. K. , Evren V. , Unak P.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.318, no.3, pp.1973-1989, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 318 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.1007/s10967-018-6282-6
  • Title of Journal : JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Page Numbers: pp.1973-1989

Abstract

In this study, we designed and synthesized [F-19]FDG-(2-deoxy-2-[fluorine-19]fluoro-d-glucose) conjugated iron oxide magnetic nanoparticles ([F-19]FDG-MNPs) for hybrid imaging and hyperthermia treatment. MNPs were synthesized, silica coated, and fabricated with TEOS (tetraethyl orthosilicate). They were then covered with hyaluronic acid (HA) to enhance their bioavailability. The modified MNPs were conjugated with [F-19]FDG and optically labeled with ICG (indocyanine green). The in vitro bioaffinities were surveyed in MCF7 and PC3 cell lines. In vivo bioaffinies were determined using Sprague-Dawley rats.