Decellularised extracellular matrix-based biomaterials for repair and regeneration of central nervous system


Yaldiz B., Saglam-Metiner P., YEŞİL ÇELİKTAŞ Ö.

EXPERT REVIEWS IN MOLECULAR MEDICINE, vol.23, 2022 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 23
  • Publication Date: 2022
  • Doi Number: 10.1017/erm.2021.22
  • Title of Journal : EXPERT REVIEWS IN MOLECULAR MEDICINE
  • Keywords: Brain decellularisation, central nervous system, extracellular matrix, spinal cord decellularisation, stem cells, SUPERCRITICAL CARBON-DIOXIDE, NONTHERMAL IRREVERSIBLE ELECTROPORATION, MESENCHYMAL STEM-CELLS, SPINAL-CORD, ACELLULAR SCAFFOLD, BIOLOGIC SCAFFOLDS, BRAIN, HYDROGELS, TISSUES, STABILITY

Abstract

The central nervous system (CNS), consisting of the brain and spinal cord, regulates the mind and functions of the organs. CNS diseases, leading to changes in neurological functions in corresponding sites and causing long-term disability, represent one of the major public health issues with significant clinical and economic burdens worldwide. In particular, the abnormal changes in the extracellular matrix under various disease conditions have been demonstrated as one of the main factors that can alter normal cell function and reduce the neuroregeneration potential in damaged tissue. Decellularised extracellular matrix (dECM)-based biomaterials have been recently utilised for CNS applications, closely mimicking the native tissue. dECM retains tissue-specific components, including proteoglycan as well as structural and functional proteins. Due to their unique composition, these biomaterials can stimulate sensitive repair mechanisms associated with CNS damages. Herein, we discuss the decellularisation of the brain and spinal cord as well as recellularisation of acellular matrix and the recent progress in the utilisation of brain and spinal cord dECM.