Enhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7

KARACA B., Atmaca H., Uzunoglu S., KARABULUT B. , ŞANLI U. A. , Uslu R.

JOURNAL OF BUON, cilt.14, ss.479-485, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 14 Konu: 3
  • Basım Tarihi: 2009
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.479-485


Purpose: Gossypol is a natural polyphenolic compound extracted from cotton plant (Gossypium species) which has shown potent inhibitory effect on cell growth of many types of cancers. In this study, we aimed to evaluate the interaction of gossypol with some conventional drugs known to be effective in the treatment of breast cancer like taxanes, doxorubicin, gemcitabine, cisplatin and vinorelbine, in MCF-7 breast cancer cells.