Nitric oxide and the endothelium: History and impact on cardiovascular disease

Yetik-Anacak G. , CATRAVAS J. D.

VASCULAR PHARMACOLOGY, vol.45, no.5, pp.268-276, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2006
  • Doi Number: 10.1016/j.vph.2006.08.002
  • Title of Journal : VASCULAR PHARMACOLOGY
  • Page Numbers: pp.268-276


There are few discoveries with the magnitude of the impact that NO has had on biology during the 25 years since its discovery. There is hardly a disease today not associated with altered NO homeostasis. In fact, despite numerous other endothelial functions, endothelial dysfunction has become synonymous with reduced biological activity of NO.