Spacer fabrics are three dimensional knitted fabrics which consist of two fabric layers combining with a spacer yarn. The characteristics of spacer fabrics become a highly interested concept for textile researchers because of increasing usage in various areas. In this study the compression characteristic which is one of the important properties of spacer fabrics was investigated. Weft knitted spacer fabric samples were produced using different spacer yarn types and various materials for back and face surfaces of the fabrics for three different dial heights. It was found that the compression resistance of the spacer fabrics is significantly affected from the spacer yarn type, dial height and surface material. The spacer fabrics with polyester surfaces and monofilament spacer yarn have higher compression resistance as the dial height increases.