Fatal disseminated Acremonium strictum infection in a preterm newborn: a very rare cause of neonatal septicaemia


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Yalaz M. , Hilmioglu S. , Metin D. Y. , Akisu M. , Nart D. , ÇETİN H., ...More

JOURNAL OF MEDICAL MICROBIOLOGY, vol.52, no.9, pp.835-837, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 9
  • Publication Date: 2003
  • Doi Number: 10.1099/jmm.0.05140-0
  • Title of Journal : JOURNAL OF MEDICAL MICROBIOLOGY
  • Page Numbers: pp.835-837

Abstract

Species of the genus Acremonium (Cephalosporium) are opportunistic micro-organisms that are environmentally widespread saprophytes in soil and can, very rarely, be pathogenic in humans. Disseminated infection has been described in patients with immunodeficiency, but has previously been reported in only one neonate. A preterm infant with Acremonium strictum fungaemia is reported here. The patient was born at 27 weeks gestation and weighed 870 g at birth. She needed intensive respiratory management and became septic on day 11 of life. Blood and cerebrospinal fluid (CSF) cultures were positive for A. stricturn. The patient did not respond to therapy with amphotericin B plus fluconazole and died on day 25 of life. The autopsy showed foci due to A. stricturn in the brain, liver and heart.