JOURNAL OF PERIODONTOLOGY, cilt.71, ss.50-57, 2000 (SCI İndekslerine Giren Dergi)
Background: Cyclosporine A (CsA) is a potent immunosuppressant effectively used to prevent organ transplant rejection and also to treat several systemic diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of the present study was to identify the role of leukotriene B-4 (LTB4) and platelet activating factor (PAF) in the pathogenesis of CsA GO.