Levels of leukotriene B-4 and platelet activating factor in gingival crevicular fluid in renal transplant patients receiving cyclosporine A


Emingil G. , Coker I., Atilla G. , Huseyinov A.

JOURNAL OF PERIODONTOLOGY, cilt.71, ss.50-57, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 71 Konu: 1
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1902/jop.2000.71.1.50
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Sayfa Sayıları: ss.50-57

Özet

Background: Cyclosporine A (CsA) is a potent immunosuppressant effectively used to prevent organ transplant rejection and also to treat several systemic diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of the present study was to identify the role of leukotriene B-4 (LTB4) and platelet activating factor (PAF) in the pathogenesis of CsA GO.