Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury

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Bakshi A., Fisher O., Dagci T. , Himes B., Fischer I., Lowman A.

JOURNAL OF NEUROSURGERY-SPINE, cilt.1, ss.322-329, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 1 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.3171/spi.2004.1.3.0322
  • Sayfa Sayıları: ss.322-329


Object. Spinal cord injury (SCI) is a complex pathological entity, the treatment of which requires a multipronged approach. One way to integrate different therapeutic strategies for SCI is to develop implantable scaffolds that can deliver therapies in a synergistic manner. Many investigators have developed implantable "bridges," but an important property of such scaffolds-that is, mechanical compatibility with host tissues-has been neglected. In this study, the authors evaluated the results of implanting a mechanically matched hydrogel-based scaffold to treat SCI.