Nicotine withdrawal in selectively bred high and low nicotine preferring rat lines

NESİL T., KANIT L. , UĞUR M., POGUN S.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.131, ss.91-97, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 131
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.pbb.2015.02.009
  • Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Sayfa Sayıları: ss.91-97

Özet

Background: We have generated high- and low-nicotine preferring (high-NP, low-NP) rat lines using voluntary oral nicotine intake as the selection criterion. After nine generations, the estimated realized heritability for high intake was 0.26. The aim of the current study is to compare how nicotine withdrawal varies between these two lines. This new analysis would help elucidate if nicotine withdrawal and intake share common genetic mechanisms.