A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations


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Karavana S. Y. , Gökçe E. H. , Rençber S. , Ozbal S., Pekcetin C., Güneri P. , ...More

INTERNATIONAL JOURNAL OF NANOMEDICINE, vol.7, pp.5693-5704, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2012
  • Doi Number: 10.2147/ijn.s36883
  • Title of Journal : INTERNATIONAL JOURNAL OF NANOMEDICINE
  • Page Numbers: pp.5693-5704
  • Keywords: SLNs, buccal application, wound healing, oral mucosal disease, PLACEBO-CONTROLLED TRIAL, DOUBLE-BLIND, RHEOLOGICAL CHARACTERIZATION, MUCOADHESIVE PROPERTIES, PERIODONTAL-DISEASE, CLINICAL-EVALUATION, POLYMERIC SYSTEMS, IN-VITRO, DELIVERY, ULCERATION

Abstract

Aim: To develop a suitable buccal bioadhesive gel formulation containing cyclosporine A solid lipid nanoparticles (CsA SLNs) for the treatment of recurrent aphthous stomatitis.