Hemophagocytic syndrome associated with inappropriate secretion of antidiuretic hormone in lymphoma and acute myeloblastic leukemia: Report of two cases


DEMİRKAN F., VURAL F. , ÖZSAN G. H. , ÖZCAN M. A. , ÖZKAL S., ÜNDAR B.

LEUKEMIA & LYMPHOMA, vol.42, no.6, pp.1401-1404, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 6
  • Publication Date: 2001
  • Doi Number: 10.3109/10428190109097769
  • Title of Journal : LEUKEMIA & LYMPHOMA
  • Page Numbers: pp.1401-1404

Abstract

Hemophagocytic syndrome (HPS) is a rare clinicopathological disorder characterized by systemic proliferation of phagocytizing histiocytes associated with fever, cytopenias, lymphadenopathy, hepatosplenomegaly, and disseminated intravascular coagulopathy. We present the association of hemophagocytic syndrome associated with inappropriate secretion of antidiuretic hormone (SIADH) in two cases of hematological malignancies; anaplastic large cell lymphoma (ALCL) and acute myeloblastic leukemia (AML M4) In the patient with lymphoma, the diagnosis of lymphoma, HPS and SIADH were concurrent. In the patient with AML, HPS and SIADH were observed while the patient was in hematological remission. Thus it seems that patients with HPS may also carry a risk for the development of SIADH; the relationship with HPS and SIADH should be further investigated.