The relationship of the methylenetetrahydrofolate reductase C6(77)T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy


Eroglu Z. , ERDOGAN M. , TETIK A. , KARADENIZ M., CETINALP S., KOSOVA B. , ...Daha Fazla

DIABETES-METABOLISM RESEARCH AND REVIEWS, cilt.23, ss.621-624, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 23 Konu: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/dmrr.735
  • Dergi Adı: DIABETES-METABOLISM RESEARCH AND REVIEWS
  • Sayfa Sayıları: ss.621-624

Özet

Background Poor glycaemic control, hypertension and duration of diabetes are risk factors for the development of diabetic nephropathy, but there may be genetic factors. Recently, a common C to T mutation at nucleotide position 677 of the MTHFR gene (MTHFR677C>T) has been reported to be correlated with hyperhomocysteinemia and the severity of coronary artery disease as macroangiopathy. We aim to investigate Turkish type 2 diabetic patients with/without diabetic nephropathy and healthy group and examine the contribution of the MTHFR gene polymorphism to the development of diabetic nephropathy.