Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment


AKAGUNDUZ O. , KARACA B., Atmaca H., Uzunoglu S., KARABULUT B. , SANLI U. A. , ...Daha Fazla

JOURNAL OF BUON, cilt.15, ss.763-767, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 4
  • Basım Tarihi: 2010
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.763-767

Özet

Purpose: Many drugs have been tested to increase the sensitivity of prostate cancer cells to radiotherapy Gossypol, a natural polyphenolic compound extracted from the cotton plant, is one of the agents the efficacy of which has been investigated in the treatment of prostate cancer for this purpose. The main aim of this study was to investigate the best gossypol application with irradiation, when gossypol was applied either sequentially (24 h before and after irradiation) or concurrently in PC-3 hormone-refractory and radioresistant prostate cancer cells.