Akademik Veri Yönetim Sistemi
XXXVII Congress of ESCRS, Paris, Fransa, 14 - 18 Eylül 2019, ss.112-113
Purpose:
To
evaluate the dry eye tests and Meibomian gland (MG) dysfunction of patients
with Stevens-Johnson Syndrome.
Methods:
Twelve
eyes of 6 patients with Stevens-Johnson Syndrome who had chronic ocular
involvement (Group 1) and 30 eyes of 15 healthy individuals (Group 2) were
enrolled. Comprehensive eye examination along with corneal and conjunctival
fluorescein staining and Oxford scoring, tear film break-up time, Schirmer 1
test, ocular surface disease index (OSDI) score assessment, and evaluation of
upper and lower eyelid MG using infrared filter of slit-lamp biomicroscope
(SL-D701 with DC-4 digital camera and BG-5 background illuminator, TOPCON, Tokyo, Japan) were performed
(from grade 0 (no
loss of MG) to grade 3 (gland dropout >2/3 of the total MG).
Results:
The
mean ages of Group 1 and Group 2 were 42.2±9.9 (range, 31-58) and 45.4±11.7
(range, 33-59), respectively (p=0.997). In Group 1, mean best-corrected visual
acuity, Schirmer 1 test and tear film break-up time was lower, while Oxford
scale and OSDI scores were higher significantly in comparison to Group 2
(p<0.05). The lower, upper and total (upper + lower) meiboscores were 2.8±0.4
(range, 2-3), 2.9±0.3 (range, 2-3) and 5.7±0.6 (range, 5-6) respectively and
significantly higher than Group 2 (p<0.001, for all variables).
Conclusion:
Stevens-Johnson
Syndrome is associated with MG dysfunction that can objectively be demonstrated
with meibography, in addition to other ocular surface problems.
Key
Words:
dry eye, ocular surface, Meibomian gland dysfunction, meibography,
Stevens-Johnson Syndrome