Evaluation of ocular surface and Meibomian gland dysfunction in patients with Stevens-Johnson syndrome

Karaca I. , Barut Selver Ö. , Palamar Onay M. , Eğrilmez S. , Yağcı A.

XXXVII Congress of ESCRS, Paris, Fransa, 14 - 18 Eylül 2019, ss.112-113

  • Basıldığı Şehir: Paris
  • Basıldığı Ülke: Fransa
  • Sayfa Sayıları: ss.112-113


Purpose: To evaluate the dry eye tests and Meibomian gland (MG) dysfunction of patients with Stevens-Johnson Syndrome.

Methods: Twelve eyes of 6 patients with Stevens-Johnson Syndrome who had chronic ocular involvement (Group 1) and 30 eyes of 15 healthy individuals (Group 2) were enrolled. Comprehensive eye examination along with corneal and conjunctival fluorescein staining and Oxford scoring, tear film break-up time, Schirmer 1 test, ocular surface disease index (OSDI) score assessment, and evaluation of upper and lower eyelid MG using infrared filter of slit-lamp biomicroscope (SL-D701 with DC-4 digital camera and BG-5 background illuminator, TOPCON, Tokyo, Japan) were performed (from grade 0 (no loss of MG) to grade 3 (gland dropout >2/3 of the total MG).

Results: The mean ages of Group 1 and Group 2 were 42.2±9.9 (range, 31-58) and 45.4±11.7 (range, 33-59), respectively (p=0.997). In Group 1, mean best-corrected visual acuity, Schirmer 1 test and tear film break-up time was lower, while Oxford scale and OSDI scores were higher significantly in comparison to Group 2 (p<0.05). The lower, upper and total (upper + lower) meiboscores were 2.8±0.4 (range, 2-3), 2.9±0.3 (range, 2-3) and 5.7±0.6 (range, 5-6) respectively and significantly higher than Group 2 (p<0.001, for all variables).

Conclusion: Stevens-Johnson Syndrome is associated with MG dysfunction that can objectively be demonstrated with meibography, in addition to other ocular surface problems.

Key Words: dry eye, ocular surface, Meibomian gland dysfunction, meibography, Stevens-Johnson Syndrome