The effect of pre-operative lornoxicam and ketoprofen application on the morphine consumption of post-operative patient-controlled analgesia

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KARAMAN S., Gunusen I. , UYAR M., FIRAT V.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.34, ss.168-175, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1177/147323000603400206
  • Sayfa Sayıları: ss.168-175


We compared the efficacy of preoperative intramuscular lornoxicam and ketoprofen for post-operative analgesia in patients undergoing abdominal hysterectomy. This randomized, double-blind, placebo-controlled, parallel-group study investigated 60 patients who received lornoxicam. (group L, 8 mg), ketoprofen (group K, 100 mg) or saline (group C) 60 min before standard anaesthesia. All patients received patient-controlled analgesia (intravenous morphine) during the post-operative period. Visual analogue scale (VAS) scores recorded 2, 4, 6 and 12 h after surgery in groups L and K patients were significantly lower than in group C patients, and VAS scores at 2, 4 and 6 h in group L patients were significantly lower than those in group K patients. Morphine consumption in groups L and K was significantly lower than in group C. Pre-emptive administration of lornoxicam. and ketoprofen effectively reduced Post-operative pain and morphine consumption, and lornoxicam was more effective than ketoprofen in the early post-operative period.