Analysis of YKL-40 Acute-Phase Protein and Interleukin-6 Levels in Periodontal Disease

Keles Z. P. , Keles G. C. , Avci B., Cetinkaya B. O. , EMİNGİL G.

JOURNAL OF PERIODONTOLOGY, cilt.85, ss.1240-1246, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 85 Konu: 9
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1902/jop.2014.130631
  • Sayfa Sayıları: ss.1240-1246


Background: YKL-40, a new acute-phase protein, is shown to be elevated in inflammatory diseases, such as rheumatoid arthritis, type 2 diabetes mellitus, and coronary artery diseases. However, there is no data indicating a relationship between YKL-40 and periodontal disease. Interleukin-6 (IL-6) is the major regulator of acute-phase protein synthesis and one of the most studied inflammatory markers in periodontal disease. The purpose of the present study is to evaluate YKL-40 and IL-6 levels in gingival crevicular fluid (GCF) and serum of patients with periodontal disease and healthy individuals.