Carbamylated low-density lipoprotein induces proliferation and increases adhesion molecule expression of human coronary artery smooth muscle cells

AŞCI, GÜLAY; Basci, ALİ; SHAH, Sudhir; BASNAKIAN, Alexei; TÖZ, HÜSEYİN; ÖZKAHYA, MEHMET; DUMAN, SONER; OK, ERCAN

doi:10.1111/j.1440-1797.2008.00948.x

Carbamylated low-density lipoprotein induces proliferation and increases adhesion molecule expression of human coronary artery smooth muscle cells

Atıf İçin Kopyala

AŞCI G. , Basci A. , SHAH S. V. , BASNAKIAN A., TÖZ H. , ÖZKAHYA M. , ...Daha Fazla

NEPHROLOGY, cilt.13, ss.480-486, 2008 (SCI İndekslerine Giren Dergi)

Cilt numarası: 13 Konu: 6
Basım Tarihi: 2008
Doi Numarası: 10.1111/j.1440-1797.2008.00948.x
Dergi Adı: NEPHROLOGY
Sayfa Sayıları: ss.480-486

Özet

Aim: Presence of accelerated atherosclerosis in dialysis patients cannot be entirely explained by conventional risk factors. Exposure to urea, which is elevated in patients with kidney disease, leads to the carbamylation of proteins. We investigated the effects of carbamylated low-density lipoprotein (cLDL) on human coronary artery vascular smooth muscle cells (VSMC).