Carbamylated low-density lipoprotein induces proliferation and increases adhesion molecule expression of human coronary artery smooth muscle cells


AŞCI G. , Basci A. , SHAH S. V. , BASNAKIAN A., TÖZ H. , ÖZKAHYA M. , ...Daha Fazla

NEPHROLOGY, cilt.13, ss.480-486, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Aim: Presence of accelerated atherosclerosis in dialysis patients cannot be entirely explained by conventional risk factors. Exposure to urea, which is elevated in patients with kidney disease, leads to the carbamylation of proteins. We investigated the effects of carbamylated low-density lipoprotein (cLDL) on human coronary artery vascular smooth muscle cells (VSMC).