PLGA encapsulation and radioiodination of indole-3-carbinol: investigation of anticancerogenic effects against MCF7, Caco2 and PC3 cells by in vitro assays


YILDIZ G., Kilcar A. Y. , MEDİNE E. İ. , TEKİN V., Guldu O. K. , Muftuler F. Z.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.311, ss.1043-1052, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 311 Konu: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s10967-016-4929-8
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.1043-1052

Özet

Encapsulation with PLGA of I3C and radioiodination have been performed. Anticancerogenic effects of I3C and I3C-PLGA have been investigated utilizing in vitro methods on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. Characterization of I3C-PLGA have been performed with DLS method and SEM analysis. I3C and I3C-PLGA compounds have been radiolabeled in high yields with I-131 which is widely used for diagnosis and treatment in Nuclear Medicine. All experimental results demonstrated that radioiodinated compounds are promising in order to be used in Nuclear Medicine as well as present study contributed previously reported studies.