In this study, the effects of thermo-mechanical processes on the 110 K phase of Bi2-x Pb (x) Sr2Ca2Cu3O (y) (x = 0.3-0.6) superconductors have been studied. In order to investigate the effects of thermo-mechanical processes, the samples were prepared in three groups with different sintering temperatures having intermediate grindings and pressings. The superconducting and structural properties of BPSCCO system were characterized by R(T), chi(T), and J (c) measurements; XRD; and SEM analysis. The thermo-mechanical processes were investigated to explain how they affect T (c) and metallic properties of the samples. According to the analysis, we obtained that the 110 K phase of BPSCCO samples was significantly affected by these thermal and mechanical processes. The preparation conditions were optimized in order to obtain a BPSCCO system having dominant phase of 110 K with the superior superconducting properties.