Antimicrobial photodynamic therapy against Staphylococcus aureus using zinc phthalocyanine and zinc phthalocyanine integrated TiO2 nanoparticles

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Tuncel A., Ozturk I., Ince M., Ocakoglu K., Hosgor-Limoncu M. , Yurt F.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, cilt.23, ss.206-212, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 23
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1142/s1088424619500238
  • Sayfa Sayıları: ss.206-212


Antibiotic resistance is an increasing healthcare problem worldwide. In the present study, the effects of antimicrobial photodynamic therapy (APDT) of ZnPc and ZnPc-integrated TiO2 nanoparticles (ZnPc-TiO2) were investigated against Staphylococcus aureus. A light emitting diode (LED) (630-700 nm, 17.4 mW/cm(2)) was used on S. aureus at different light doses (8 J/cm(2) for 11 min, 16 J/cm(2) for 22 min, 24 J/cm(2) for 33 min) in the presence of the compounds under the minimum inhibitory concentration values. Both compounds showed similar phototoxicity toward S. aureus when high light doses (16 and 24 J/cm(2)) were applied. In addition, the success of APDT increased with an increasing light dose.