Constrictive Aspergillosis Pericarditis


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Karaca N.

in: Pediatric Immunology, A case-based collection with MCQs, vol II, Nima Rezaei, Editor, Springer, London/Berlin , Chur, pp.333-339, 2019

  • Publication Type: Book Chapter / Chapter Other Book
  • Publication Date: 2019
  • Publisher: Springer, London/Berlin 
  • City: Chur
  • Page Numbers: pp.333-339
  • Editors: Nima Rezaei, Editor

Abstract

A 3-month-old girl was referred to our hospital with a suspicion of Langerhans cell

histiocytosis. She was hospitalized for pneumonia at the 15th day of birth followed

by recurrent and treatment resistant cervical lymphadenopathies with high CRP levels.

She was the first child of a consanguineous family. She had bilateral cervical

lymphadenopathies and maculopapular skin eruptions over body and legs on admission.

Laboratory investigations revealed anemia, leukocytosis, high CRP level

(12 mg/dL), and hypergammaglobulinemia. Histological findings of the skin biopsy

and lymph node excision were reported as granulomatous inflammation and necrotizing

granulomatous lymphadenitis, respectively. Meanwhile, oxidative burst

activity (“Phagoburst” kit, Glycotope, Biotechnology) was insufficient leading to a

probable diagnosis of chronic granulomatous disease (CGD) later confirmed with

mutation analysis disclosing a “homozygous autosomal recessive c.369+1G>A

mutation” in CYBA gene - p22phox. Flow cytometry is currently the method used to

validate the oxidative capacity of neutrophils