Tc-99-exorphin C: A new peptide radiopharmaceutical for tumor imaging


ERTAY T., Unak P. , TASCI C., BIBER F., Zihnioglu F. , DURAK H. İ.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.265, ss.473-479, 2005 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 265 Konu: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s10967-005-0851-1
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.473-479

Özet

The aim of this study was to label exorphin C with Tc-99m and to examine its usefulness as opioid receptor binding radiopharmaceutical in Albino Wistar rats. Exorphin C, which is a peptide with 5 aminoacids, was labeled with Tc-99m using glucoheptonate (GH) as a bifunctional chelating agent. Labeling efficiency was higher than 98%. The compound was stable for at least 5 hours at room temperature. Mammary tumor bearing Albino Wistar rats were imaged using gamma-camera. Biodistribution studies were also performed. Results demonstrated that Tc-99m-glucoheptonate-exorphin C(Tc-99m-GE) analogs may be useful as a new class of receptor-binding peptides for the diagnosis and therapy of some cancer diseases related with opioid receptor-expressing tissues.