Recently, entrepreneurship is emerging as an important concept in creating economic growth and employment. The human factor is the structure should be evaluated primarily on entrepreneurship. This study aimed to examine the relationship between entrepreneurial individual personality characteristics. Method: The articles that are related with entrepreneurship, personality, neurosis, extroversion were searched by key words in PubMed, Medline, EBSCOHost, PsycINFO, Science Direct, Turkish Medline, Cukurova Index Databases and in Google Scholar and those appropriate for this review were used by authors. Expected Results: Conclusion: Our study revealed the influence of individual differences on entrepreneurship. studies showing that impact on the behavior of personality traits, will be a guide to future entrepreneurs. Personality include sustainability aspects of individual's mental, emotional, social and physical. Meta-analytic studies showed that individual differences effect on entrepreneurial orientation. Entrepreneurs were determined to be risk-taking, innovative, high sense of responsibility, high communication skills individuals. Especially in biological studies, it was determined that extraversion and neurotic structure increase entrepreneurship.