Hypocholesterolemia is seen in solid tumors and some hematological malignancies. We assessed cholesterol levels and the relationship between these levels and types and stages of multiple myeloma (MM) in the patients with MM. One-hundred two patients (60 male and 42 female) of mean age 59 +/- 11 years with MM were enrolled to this study. While 71.6% of the patients were Ig G type, 80.4% of the patients were at stage III. In the control group, there were 71 healthy persons (42 male and 29 female) of mean age 58 +/- 8 years. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in the patients with MM were significantly lower than the controls (p<0.001). There was no difference for the levels of very-low-density lipoprotein cholesterol and triglyceride between the two groups (p>0.05). Lipid parameters were not different between Ig types (p>0.05). The levels of TC and LDL-C in the patients with stage I were higher than those of stages II and III (p<0.001 and p<0.005, respectively). The levels of TC and LDL-C in the controls were not higher than the patients with stage I (p>0.05). HDL-C levels in the patients with stage III were lower than controls (p<0.001). Hypocholesterolemia are seen in the patients with MM. Hypocholesterolemia may be due to increased LDL clearance and utilization of cholesterol by myeloma cells.