The prevalence of RET/PTC mutations in papillary thyroid cancers in Turkish population and its relation between tumor histopathology and prognostic factors


ERDOĞAN M. , BERDELİ A. , KARADENİZ M., ERTAN Y. , ÇETİNKALP Ş. , Saygili F., ...Daha Fazla

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, cilt.116, ss.225-230, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 116 Konu: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1055/s-2007-992153
  • Dergi Adı: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Sayfa Sayıları: ss.225-230

Özet

Objective: In recent years, thyroid cancer has been at the forefront of molecular pathology as a result of the consequences of the Chernobyl disaster and the recognition of the role of RET/PTC rearrangements in papillary thyroid carcinomas (PTCs). Correlation of RET/PTC expression with clinical outcome is controversial. This study aims to identify the prevalence of RET/PTC oncogene expression in Turkey, and to investigate the correlation between RET/PTC oncogene expression and the known prognostic factors of PTC in 101 patients.