Lacidipine has antiatherosclerotic effects independent of its actions on lipid metabolism and blood pressure

Anacak G. , Ustunes L., Dilsiz Ö. , ERGUL A.

VASCULAR PHARMACOLOGY, vol.53, pp.193-199, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53
  • Publication Date: 2010
  • Doi Number: 10.1016/j.vph.2010.08.003
  • Title of Journal : VASCULAR PHARMACOLOGY
  • Page Numbers: pp.193-199


The antiatherosclerotic effect of lacidipine has been attributed to its actions on cholesterol levels, lipid metabolism or oxidant stress in advanced disease. The purpose of the present experiments was to examine whether lacidipine is protective of intimal thickening and vascular dysfunction in early atherosclerosis in the absence of the hypertension and hypercholesterolemia. A second goal was to determine whether and to what extent MMP-9 and oxidant stress are involved in possible beneficial effects of lacidipine.