Oleanane type glycosides from Paronychia anatolica subsp balansae


GÜLCEMAL D. , MASULLO M., ALANKUS-CALISKAN Ö. , PIACENTE S.

FITOTERAPIA, cilt.92, ss.274-279, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Four new oleanane-type triterpene glycosides were isolated from the methanol extract of the roots of Paronychia anatolica subsp. balansae along with three known oleanane-type triterpene glycosides. Structures of the new compounds were established as 3-O-beta-D-glucuronopyranosyl-28-O-[alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-quinovopyranoside] zahnic acid, 3-O-beta-D-glucuronopyranosyl-28-O-[beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-quinovopyranoside] zahnic acid, 3-O-beta-D-glucuronopyranosyl-28-O-[alpha-L-arabinofuranosyl(1 -> 2)-beta-D-quinovopyranoside] zahnic acid, 28-O-beta-D-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl]-medicagenic acid, by using 1D and 2D-NMR techniques and mass spectrometry. The cytotoxic activity of the isolated compounds was evaluated against a small panel of cancer cell lines including human breast cancer (MCF-7), human lung adenocarcinoma (A549) and human leukemia (U937) cell lines. (C) 2013 Elsevier B.V. All rights reserved.