Cycloartane glycosides from Astragalus plumosus var. krugianus and evaluation of their antioxidant potential


DENIZLI N., HORO I., GÜLCEMAL D. , MASULLO M., FESTA M., CAPASSO A., ...More

FITOTERAPIA, vol.92, pp.211-218, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92
  • Publication Date: 2014
  • Doi Number: 10.1016/j.fitote.2013.10.018
  • Title of Journal : FITOTERAPIA
  • Page Numbers: pp.211-218

Abstract

The methanol extracts of Astragalus plumosus var. krugianus Chamb. & Matthews afforded sixteen cycloartane glycosides among which krugianoside A, was never reported before. All compounds were evaluated for their cytotoxic activity in human skin fibroblast WS1 cells. For compounds exhibiting no significant effect on WS1 viability, the antioxidant potential was examined. Compounds 1 and 8 prevented elevation of ROS induced by t-BOOH, suggesting the potential activity of these compounds to protect fibroblasts from oxidative stress. (C) 2013 Elsevier B.V. All rights reserved.