Effectiveness of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid laminin-5 gamma 2 chain levels in chronic periodontitis


EMINGIL G. , Atilla G. , SORSA T., SAVOLAINEN P., BAYLAS H.

JOURNAL OF PERIODONTOLOGY, cilt.75, ss.1387-1396, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 75 Konu: 10
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1902/jop.2004.75.10.1387
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Sayfa Sayıları: ss.1387-1396

Özet

Background: Laminin-5 (Ln-5) is involved in the apical migration of epithelial cells during the development of periodontal pockets. Low-dose doxycycline (LDD) can therapeutically modulate the host response with its non -antimicrobial properties. In the present randomized, double-blind, placebo-controlled, parallel arm study, the effectiveness of LDD in combination with non-surgical periodontal therapy on gingival crevicular fluid (GCF) Ln-5,gamma2 chain fragment levels and clinical parameters in patients with chronic periodontitis was examined over a 12-month period.