Yarns made of natural and man-made cellulose fibers are nowadays commonly applied in textiles. It is already apparent that the type of raw material and fabric structure influences the properties of the comfort. While designing a fabric, functional properties and basic structural parameters of fabrics must be fully understood. Clothing comfort is closely related to thermal comfort. The aim of this paper is to present a comparative of thermal comfort properties such as thermal resistance, thermal conductivity, thermal absorptivity, water vapour permeability, air permeability, and other properties for fabrics made of cotton, tencel, modal and cupro yarns. Samples were measured with the aid of Alambeta, Permetest, and Textest FX3000 devices respectively. The results of the tests were evaluated statistically and the importance levels of the relationship between the measured parameters were determined.