Functional convergence of Akt protein with VEGFR-1 in human endothelial progenitor cells exposed to sera from patient with type 2 diabetes mellitus

HASSANPOUR, Mehdi; REZABAKHSH, Aysa; RAHBARGHAZI, Reza; NOURAZARIAN, Alireza; NOURİ, Mohammad; Avci, ÇIĞIR; GHADERİ, Shahrooz; ALİDADYANİ, Neda; Bagca, BAKİYE; BAGHERİ, Hesam

doi:10.1016/j.mvr.2017.07.002

Functional convergence of Akt protein with VEGFR-1 in human endothelial progenitor cells exposed to sera from patient with type 2 diabetes mellitus

Atıf İçin Kopyala

HASSANPOUR M., REZABAKHSH A., RAHBARGHAZI R., NOURAZARIAN A., NOURİ M., Avci C. B. , ...Daha Fazla

MICROVASCULAR RESEARCH, cilt.114, ss.101-113, 2017 (SCI İndekslerine Giren Dergi)

Cilt numarası: 114
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.mvr.2017.07.002
Dergi Adı: MICROVASCULAR RESEARCH
Sayfa Sayıları: ss.101-113

Özet

Diabetes mellitus type 2 predisposes patients to various microvascular complications. In the current experiment, the potent role of diabetes mellitus was investigated on the content of VEGFR-1,-2, Tie-1 and-2, and Akt in human endothelial progenitor cells. The gene expression profile of mTOR and Hedgehog signaling pathways were measured by PCR array. The possible crosstalk between RTKs, mTOR and Hedgehog signaling was also studied by bioinformatic analysis.