JAK/STAT pathway interacts with intercellular cell adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) while prostate cancer stem cells form tumor spheroids


DUZAGAC F., Inan S., Simsek F. E. , Acikgoz E. , GUVEN U., KHAN S. A. , ...Daha Fazla

JOURNAL OF BUON, cilt.20, ss.1250-1257, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 5
  • Basım Tarihi: 2015
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.1250-1257

Özet

Purpose: JAK/STAT is an evolutionarily conserved pathway and very important for second messenger system. This pathway is important in malignant transformation and accumulated evidence indicates that this pathway is involved in tumorigenesis and progression of several cancers. It was possible to assume that activation of JAK/STAT pathway is associated with increase in the expressions of ICAM-1 and VCAM-1. In this study we hypothesized that when cells were maintained as spheroids or monolayers, the structure of cancer stem cells (CSCs) could show differentiation when compared with non-CSCs.