Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women


Akyildiz Z. I. , POLAT S., Yurekli B. P. , Kocabas G. U. , TÜLÜCE K., Tuluce S. Y. , ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.38, no.3, pp.361-366, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1007/s40618-014-0185-3
  • Title of Journal : JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Page Numbers: pp.361-366

Abstract

Purpose The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles.