New coumarin glycosides from endemic Prangos heyniae H. Duman & MF Watson


Albayrak G., DEMİR S. , Kose F. A. , BAYKAN ÖZTÜRK Ş.

NATURAL PRODUCT RESEARCH, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1080/14786419.2021.1961138
  • Title of Journal : NATURAL PRODUCT RESEARCH
  • Keywords: Prangos, Apiaceae, coumarin, cytotoxicity, ANTIOXIDANT ACTIVITIES, ESSENTIAL OIL, CONSTITUENTS, PLANT, FURANOCOUMARIN, APIACEAE, FRUITS, IDENTIFICATION, DERIVATIVES, ANATOLIA

Abstract

Two new coumarin glycosides, named 7-methoxy isoarnottinin 4'-O-beta-D-glucopyranoside and 7-methoxy isoarnottinin 4'-O-rutinoside (1 and 2) along with six known compounds (3-8) were isolated from the roots of Prangos heyniae, an endemic plant of Turkey. 1-methylethyl 6-O-D-apio-beta-D-furanosyl-beta-D-glucopyranoside (7) and cnidioside A (8) have been obtained from the genus Prangos for the first time. Structures of isolated compounds were established using spectroscopic methods (1D and 2D NMR, HR-MS, UV and IR). Moreover, all extracts and isolated compounds were evaluated for their cytotoxic activity against NIH/3T3, HK-2, A-549, MCF-7, PC-3 and SH-SY5Y cell lines by WST-1 method. One of the new coumarin glycosides, 7-methoxy isoarnottinin 4'-O-beta-D-glucopyranoside (1) exhibited selective cytotoxic activity against SH-SY5Y cells with IC50 value of 31.41 +/- 1.04 mu M.