The total synthesis of the pavine alkaloid thalimonine


PABUÇÇUOĞLU M. V. , HESSE M.

HETEROCYCLES, vol.45, no.9, pp.1751-1758, 1997 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 9
  • Publication Date: 1997
  • Title of Journal : HETEROCYCLES
  • Page Numbers: pp.1751-1758

Abstract

The synthesis of the pavine alkaloid (+/-)-thalimonine (1) by the acid-mediated cyclization of the corresponding 1,2-dihydroisoquinoline (10) is reported. The latter compound was synthesized by a multistep reaction from 4-methoxy-2,3-methylenedioxybenzaldehyde. The resolution of (+)-1 to its (-)-enantiomer was performed.