Alarm anti-protease trappin-2 negatively correlates with proinflammatory cytokines in patients with periodontitis


Afacan B., Ozturk V. O. , EMİNGİL G. , KÖSE T. , Bostanci N.

JOURNAL OF PERIODONTOLOGY, vol.89, no.1, pp.58-66, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1902/jop.2017.170245
  • Title of Journal : JOURNAL OF PERIODONTOLOGY
  • Page Numbers: pp.58-66

Abstract

Background: Trappin-2 is a potent biologically active serine protease inhibitor with anti-inflammatory properties that has also been characterized as an "alarm anti-protease." Although the importance of trappin-2 in several chronic infections has been demonstrated, its potential involvement in periodontitis remains undefined. This study aims to investigate salivary levels of trappin-2 and interleukin (IL)-1 beta in periodontally healthy individuals and patients with gingivitis or generalized chronic periodontitis (CP) or aggressive periodontitis (GAgP).