Management of plant diseases relies substantially on the application of fungicides, bactericides and insecticides. These pesticides kill or suppress both the pathogens and their vectors. Either overuse or inappropriate use of chemical pesticides could give rise to environmental pollution, food safety concern and side effects of non-target organisms. Therefore, search for alternative ways of both reducing the use of chemical pesticides has been on the top of the agenda. Methods that increase plant immunity have been a new and rapidly developing field in plant protection research in recent years. Immunity inducers can be divided into nonbiologically and biologically active molecules. Biologically active molecules are active small molecules produced during the interaction between the pathogen and its host. They are metabolites, oligosaccharides, glycoproteins, glycopeptides, proteins, polypeptides, lipids, cerevisane obtained by yeast fermentation processes and other cellular components. Nonbiologically active molecules are synthetic immunity inducers. These are SA derivatives, Isonicotinic acid derivatives (INA), Thiadiazole and Isothiazole derivatives, JA analog and β-aminobutyric acid (BABA). The uses of plant immunity inducers in practice in plant production could decrease both the numbers of applications and the total amount of pesticides in sypraying programs, thus could contribute the development of sustainable agriculture. In this review, recent studies are included on proteins, oligosaccharides and microbial stimulants from biologically active molecules, and SA derivatives, isonicotinic acid derivatives (INA), thiadiazole and isothiazole derivatives, JA analog, β-aminobutyric acid (BABA) from synthetic immunity inducers related plant disease management.