Whole-genome gene expression analysis in urine samples of patients with prostate cancer and benign prostate hyperplasia


Ozdemir T. R. , Simsir A. , Onay H. , Cureklibatir I. , Ozkinay F. , Akin H.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, vol.35, no.10, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 10
  • Publication Date: 2017
  • Doi Number: 10.1016/j.urolonc.2017.05.020
  • Title of Journal : UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Abstract

Objective: There is an urgent need to find new biomarkers with higher specificity and sensitivity for using early detection of prostate cancer (PrCa) and reducing recurrent unnecessary biopsy rates, psychological and physical stress on the patient, and costs. Being noninvasive, urine-based tests might be suitable in routine practice. The aim of this study was to report the first whole-genome gene expression analysis in urine samples, as noninvasive method, that were obtained from PrCa, benign prostate hyperplasia (BPH), and control groups by using the microarray system from Turkey, to our knowledge.