Design of Tc-99(m) radiolabeled gemcitabine polymeric nanoparticles as drug delivery system and in vivo evaluation


İÇHEDEF Ç. , TEKSÖZ S. , Cetin O., Aydin B., Sarikavak I., Parlak Y., ...More

MATERIALS CHEMISTRY AND PHYSICS, vol.263, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 263
  • Publication Date: 2021
  • Doi Number: 10.1016/j.matchemphys.2021.124380
  • Title of Journal : MATERIALS CHEMISTRY AND PHYSICS

Abstract

The main objective of this study is to create a multifunctional drug carrier system as a prototype product. For this purpose, Gemcitabine that used as an anticancer agent for several kinds of tumour therapy, and technetium(I)-tricarbonyl core, [Tc-99m(CO)(3)](+), was incorporated to the polymeric structure.